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Tion. In control animals receiving the control GFP viral vector injection, GFP fluorescence was apparent inNasirinezhad et al. Molecular Pain 2015, 11:2 http://www.molecularpain.com/content/11/1/Page 6 ofFigure 6 Behavioral outcome of early and late injection of lentiviral constructs. Tactile allodynia in the von Frey test (A), cold allodynia in the acetone test (B), thermal hyperalgesia in the pl
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Tion. In control animals receiving the control GFP viral vector injection, GFP fluorescence was apparent inNasirinezhad et al. Molecular Pain 2015, 11:2 http://www.molecularpain.com/content/11/1/Page 6 ofFigure 6 Behavioral outcome of early and late injection of lentiviral constructs. Tactile allodynia in the von Frey test (A), cold allodynia in the acetone test (B), thermal hyperalgesia in the pl
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Ion of virally encoded opioid peptides EM-1, EM-2 with the NMDA antagonist SHG after their intraspinal injection. The expression was similar to that seen previously with these constructs in different cells [44]. The results showed that intraspinal delivery of the viral vectors mixture produced marked attenuation of neuropathic pain syndromes which lasted up to two months post injection. Antinocice
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Ion of virally encoded opioid peptides EM-1, EM-2 with the NMDA antagonist SHG after their intraspinal injection. The expression was similar to that seen previously with these constructs in different cells [44]. The results showed that intraspinal delivery of the viral vectors mixture produced marked attenuation of neuropathic pain syndromes which lasted up to two months post injection. Antinocice
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Rop in withdrawal threshold (Von Frey test) and increased sensitivity to cold stimuli (acetone test) compared to pre-injection responses (P
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Rop in withdrawal threshold (Von Frey test) and increased sensitivity to cold stimuli (acetone test) compared to pre-injection responses (P
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D the antinociceptive effects of viral vectors, asBased on the behavioral results, we examined the expression of the endomorphins and serine histogranin in the dorsal horn of the spinal cord seven weeks after viral vector injection. Sections were labeled for endomorphins or SHG immunoreactivity. Immunoreactive positive cells for SHG (A) and endomorphins (B) were seen in the dorsal horn at the 7th
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D the antinociceptive effects of viral vectors, asBased on the behavioral results, we examined the expression of the endomorphins and serine histogranin in the dorsal horn of the spinal cord seven weeks after viral vector injection. Sections were labeled for endomorphins or SHG immunoreactivity. Immunoreactive positive cells for SHG (A) and endomorphins (B) were seen in the dorsal horn at the 7th