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Rminal repeats are typically inflexible, though alternative repeat -1 modules have recently been described (24,25). We tested acBat1 deletion derivatives to test if this paradigm applies to Bat1. First, we tested variants of acBat1 lacking 2 ( 18?0), 4 ( 16?0), 6 ( 14?0) or 8 ( 12?0) core repeats (Figure 5A and Supplementary Figure S10). The later half of repeat 20 and repeat +1 were retained in e
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Rminal repeats are typically inflexible, though alternative repeat -1 modules have recently been described (24,25). We tested acBat1 deletion derivatives to test if this paradigm applies to Bat1. First, we tested variants of acBat1 lacking 2 ( 18?0), 4 ( 16?0), 6 ( 14?0) or 8 ( 12?0) core repeats (Figure 5A and Supplementary Figure S10). The later half of repeat 20 and repeat +1 were retained in e
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Lymorphism in the native Bat1 as well as being relevant for the creation of Bat1 derivatives with novel specificity (dBats). We hypothesize that nonRVD polymorphisms may have two functionally relevant, non-mutually-exclusive, effects. (i) The formation of unique but functionally equivalent repeat interfaces that stabilize the superhelical structure formed by tandem-arranged repeats (4,5) (superstr