Ct on the ability of tAg to bind p107 (Fig. 4) or p130 (data not shown). It is likely that both LxCxE motifs contribute to Rb binding, perhaps redundantly, and that to abolish binding activity, double mutants will have to be createdJCV Small t Protein Functionsand tested. It is also possible that neither LxCxE motif is required for Rb binding, as a number of cellular proteins lacking this sequence


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