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More susceptible to UTIs than are healthy patients because of the greater adherence of type 1 fimbriated E. coli to bladder cells (57). The LGI network of Candida Als and Epa adhesins N-Als1p has been shown to interact with fucose-containing glycans that are present in blood group antigens and preferentially with antigen Htype 2 (22). Therefore, we performed glycan array screening to also determin
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Of a protein altered in mutants resistant to microtubule inhibitors as a member of the major heat shock protein (hsp70) family. Mol. Cell. Biol. 10:5160?5165. 3. Alberts, B., D. Bray, J. Lewis, M. Raff, K. Roberts, and J. D. Watson. 1994. Molecular biology of the cell. Garland Publishing, Inc., New York, N.Y. 4. Allsopp, A. 1969. Phylogenetic relationships of the procaryota and the origin of the e
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Ell, T., and R. G. E. Murray. 1986. Polar lipid profiles of the genus Deinococcus. Int. J. Syst. Bacteriol. 36:202?06. 40. Craig, E. A. 1993. Chaperones: helpers along the pathways to protein folding. Science 260:1902?903. 41. Craig, E. A., B. D. Gambill, and R. J. Nelson. 1993. Heat shock proteins: molecular chaperones of protein biogenesis. Microbiol. Rev. 57:402?14. 42. Creti, R., E. Ceccarelli
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S and signature sequences: evolutionary relationships within prokaryotes and between prokaryotes and eukaryotes. Antonie Leeuwenhoek 72:49?1. 100. Gupta, R. S. 1998. Life's third domain (Archaea): an established fact or an endangered paradigm? A new proposal for classification of organisms based on protein sequences and cell structure. Theor. Popul. Biol. 54:91?104. 101. Gupta, R. S. 1998. What ar
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Of species by means of natural selection, or the preservation of favoured races in the struggle for life. John Murray, London, United Kingdom. 44. Davies, J. 1994. Inactivation of antibiotics and the dissemination of resistance genes. Science 264:375?82. 45. Deckert, G., P. V. Warren, T. Gaasterland, W. G. Young, A. L. Lenox, D. E. Graham, R. Overbeek, M. A. Snead, M. Keller, M. Aujay, R. Huber, R
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Ommon to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Proc. Natl. Acad. Sci. USA 89:7290?294. 18a.Brennan, P. J., and H. Nikaido. 1995. The envelope of mycobacteria. Annu. Rev. Biochem. 64:29?3. 19. Brooks, B. W., R. G. E. Murray, J. L. Johnson, E. Stackebrandt, C. R. Woese, and G. E. Fox. 1980. Red-pigmented micrococci: a basis for taxonomy. Int. J. Syst.
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Red asterisks in Figure 3A), as the consistently low background in the normal patients resulted in a very low scoring cutoff (both assays show 100 specificity against normal samples). Next, by combining the most robust TAA observed in our studies, p53, with sandwich immunoassay based quantification of the well-known CRC biomarker CEA, and the cytokine GDF15 in a hybrid multiplexed assay, we achie
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D reported here is ideally suited both for clinical validation and diagnostic detection of serological biomarker panels or signatures, including autoantibodies against TAAs as well as non-antibody protein biomarkers.J Immunol Methods. Author manuscript; available in PMC 2014 December 31.Ostendorff et al.PageTechnical validation of the tumor biomarker assay itself is a critical step in the developm