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Rvation will require additional investigation to determine if enhanced PP2A binding is associated with a transformed phenotype. It should be noted that to detect PP2A binding in this study, we employed antibodies that recognized the catalytic subunit of PP2A. PP2A is found abundantly as either a holoenzyme consisting of the AC core plus a regulatory B subunit, or as the AC core alone. High levels
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Asmid, pM1o, and 400 ng of one of the following expression vectors that encode JCV early genes under the control of the CMV promoter: pCMV:T+/t+/T9+ (lanes 2, 3; all five tumor proteins expressed), pCMV:T+/t2/T9+ (lanes 4, 5; TAg and 3 T9 proteins expressed) or pCMV:T+/t2/T92 (lanes 6, 7; TAg only expressed). The ability of the proteins produced by the second plasmid to drive replication of the or
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Were admitted after elective surgery were excluded that left 158 unplanned admissions in total, with only 55(34.8 ) patients surviving for more than one year. Conclusions: Although this data shows better survival for unplanned admissions than previous studies, outcomes are still poor for elderly patients who are admitted to ITU. This should inform discussions with patients and their relatives rel
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Mith, T. 1987. Eukaryotes with no mitochondria. Nature 326: 332?33. 30. Cavalier-Smith, T. 1987. The origin of eukaryotic and archaebacterial cells. Ann. N. Y. Acad. Sci. 503:17?4. 30a.Cavalier-Smith, T. 1991. The evolution of cells, p. 271?04. In S. Osawa and T. Honjo (ed.), Evolution of life. Springer-Verlag, Tokyo, Japan. 31. Cavalier-Smith, T. 1992. Origins of secondary metabolism. Ciba Found.
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Dies have confirmed this role for JCV TAg as well. Regulation of SV40 DNA replication involves the incompletely understood coordination of TAg phosphorylation and dephosphorylation. Phosphorylation of serines 120 and 123 negatively regulates TAg functions, whereas phosphorylation of threonine 124 is required for TAg-mediated replication [reviewed in 20,21]. Modifications to the corresponding resid
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Dies have confirmed this role for JCV TAg as well. Regulation of SV40 DNA replication involves the incompletely understood coordination of TAg phosphorylation and dephosphorylation. Phosphorylation of serines 120 and 123 negatively regulates TAg functions, whereas phosphorylation of threonine 124 is required for TAg-mediated replication [reviewed in 20,21]. Modifications to the corresponding resid
1
Ted with mortality in elderly (66.42 ?6.47 vs 36.34 ?12.70, P = 0.000) whereas APACHE 11, MV days, Mean blood Glucose (MBG) were not Conclusions: For the similar APACHE 2 score, elderly patients have greater glycemic variability , which could have contributed to the increased mortality. Amongst the glycemic variability indices tested, GLI was found to be better predictor than MBG.References 1. Sub