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N activator streptokinase might contribute to contact system activation by S. pyogenes. Here, we report that the human contact system is activated by the action of streptokinase. The role of secreted and surfacebound streptokinase in this process was investigated by comparing an M49 S. pyogenes wild-type strain with its isogenic ska mutant, which is unable to trigger plasmin activity in human plas
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Ct on the ability of tAg to bind p107 (Fig. 4) or p130 (data not shown). It is likely that both LxCxE motifs contribute to Rb binding, perhaps redundantly, and that to abolish binding activity, double mutants will have to be createdJCV Small t Protein Functionsand tested. It is also possible that neither LxCxE motif is required for Rb binding, as a number of cellular proteins lacking this sequence
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Dies have confirmed this role for JCV TAg as well. Regulation of SV40 DNA replication involves the incompletely understood coordination of TAg phosphorylation and dephosphorylation. Phosphorylation of serines 120 and 123 negatively regulates TAg functions, whereas phosphorylation of threonine 124 is required for TAg-mediated replication [reviewed in 20,21]. Modifications to the corresponding resid
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Function testing. Teresa L. Born is the corresponding author and is responsible for the overall design and execution of the studies. Yuh-feng Chen is the subject expert for potency assessment and he contributed to the authoring and reviewing of this manuscript. Amanda Rohrbach, Christina Pastula, and Gwen Maher are the subject experts for binding assays and they contributed to the authoring and re
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And Glycemic lability index (Exp(B) = 1.001) were significantly associated with mortality. The variables were subsequently compared beween the elderly patients (60 years) and those 60 years age Results: Multivariate logistic regression analysis was performed on variables found to be significantly associated with mortality. Age (Exp(B) = 1.735) ; APACHE Score (Exp(B) = 1.298) and Glycemic lability