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Rmer employees and stockholders of Amgen, Inc. Yuh-feng Chen, Gwen Maher, and Teresa L. Born are employees and stockholders of Amgen, Inc. Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medi