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E 6x coverage mammalian genomes were used to build a profile hidden Markov model with the software HMMER [81], which was then used to screen the platypus ab initio peptide predictions available from Ensembl. An inferred ancestral HIN domain sequence from the node that predates the split between HIN-A, -B and -C domains was also used to perform this search. The genomes of chicken (Gallus gallus rel
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Nces between GFP and single-vector injected groups were observed as well with modest, but significant differences at some time points (overall F(df 4,9) =10.1).Effect of delayed injection of viral vectors on pain behaviorTo mimic clinical scenarios, the effect of time of delivery of therapeutic agents in chronically injured animals has to be considered. Therefore we evaluated the analgesic effect
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Red DNA bases. RVD composition and target sequence are key parameters determining affinity of TALE NA interactions and these were kept constant in our dBat tests as far as possible. For the repeat switch tests, we exchanged repeats with RVDs paired to the same base in BEBat1 allowing the wildtype target construct to be used in each case. For the RVD switch constructs, where possible we exchanged R
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The vector pEMBLyex4, were introduced into the temperature-sensitive eIF2a (sui2-1, TD304-10B) mutant strain. The indicated transformants were streaked on SC-Gal medium, where eIF2a expression was maintained and the viral protein expression was induced, and incubated at the indicated temperatures. Results shown are representative of 4 independent transformants for each plasmid.Rothenburg et al. BM
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Served between early and late SHG-EM injections comparing the data up to 7 weeks post injection, with the exception of week 5, when the threshold for mechanical allodynia was significantly higher in the group injected early post SCI. *p
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Rop in withdrawal threshold (Von Frey test) and increased sensitivity to cold stimuli (acetone test) compared to pre-injection responses (P
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Served between early and late SHG-EM injections comparing the data up to 7 weeks post injection, with the exception of week 5, when the threshold for mechanical allodynia was significantly higher in the group injected early post SCI. *p